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who voted for them.Neurons of the lateral geniculate nucleus give rise to the ipsilateral oculomotor nerve.
Patterned projections in the visual system have been well described. However, studies of small fiber connections, particularly those that arise from the lateral geniculate nucleus, have primarily used antidromic stimulation of the fibers to access other brainstem and cerebellar targets. This may lead to an underestimate of the ipsilateral projections to the visual centers because the true targets of geniculocortical fibers might be other than those that were stimulated. Here we present direct electrophysiological evidence that the ipsilateral oculomotor nerve is a site of termination of the discharges of lateral geniculate nucleus (LGN) neurons. Identifying the exact termination site and origin of the ipsilateral oculomotor nerve may have implications for treatment of ocular disease and therapy of amblyopia.Population-based study of the genotype frequency of the factor V Leiden mutation.
In the UK, the prothrombin gene mutation G20210A (factor V Leiden) accounts for the vast majority of cases of inherited thrombophilia. However, no estimates of genotype frequency are available from a UK population-based study, and recent reports have suggested that the mutation is less common than in North America. We have carried out a UK-wide study of the genotype frequency of the factor V Leiden mutation, by screening the common acceptor site mutation, G1691A, at the 3′ end of the factor V gene in 2638 DNA samples obtained from 1452 unselected patients with unexplained venous thromboembolism. No evidence of the G1691A change was found in any of these samples, confirming the published low prevalence of the mutation in the UK population.c:display_name>
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